Many bacterial infections are major health problems worldwide, and treatment of many of these infectious diseases is becoming increasingly difficult due to the development of antibiotic resistance, which is a major threat. Prophylactic vaccines ...{ai:summary}<p>Bacterial infections pose significant global health challenges, exacerbated by increasing antibiotic resistance. The need for effective prophylactic vaccines is critical, especially for neglected diseases like typhus, which could resurge in conflict zones. Vaccination against these pathogens is complex due to the diverse antigens present in bacteria.</p><p>Current vaccines effectively target extracellular bacteria, but intracellular bacteria require T cell-mediated immune responses for effective defense. New vaccination strategies must focus on activating CD8+ T cells alongside traditional antibody responses to combat these pathogens. The urgency for innovative vaccines is underscored by the WHO's priority list for antibiotic-resistant bacteria. #health</p>

Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria

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