The Los Angeles County Medical Examiner revealed Matthew Perry’s cause of death on Friday afternoon.

The Los Angeles County Medical Examiner said that the "Friends" actor died as a result of "the acute effects of ketamine."

"The main lethal effects would be from both cardiovascular overstimulation and respiratory depression," the medical examiner's report said.

“There were trace amounts of ketamine detected in the stomach contents,” the report continued. “He was reported to be receiving ketamine infusion therapy for depression and anxiety.”

The "exact method of intake" of the ketamine is unknown.

Drowning on Oct. 28 in a hot tub at his home in the Pacific Palisades area of Los Angeles was also a contributor to his sudden death.

“Drowning contributes due to the likelihood of submersion into the pool as he lapsed into unconsciousness; coronary artery disease contributes due to exacerbation of ketamine-induced myocardial effects on the heart,” the report stated.

“Buprenorphine effects are listed as contributory, even though not at toxic levels, due to the additive respiratory effects when present with high levels of ketamine. Autopsy shows no fatal blunt or penetrating trauma," the coroner's report added.

Substance Abuse and Mental Health Services Administration notes, "Buprenorphine is the first medication to treat opioid use disorder (OUD) that can be prescribed or dispensed in physician offices, significantly increasing access to treatment."

"Prescription medications and loose pills" were also found at the residence of the actor best known for portraying Chandler Bing in the hit TV show "Friends."

The manner of the 54-year-old actor's death was ruled an accident. There are no signs of foul play are suspected.

Authorities confirmed that Perry was already dead when first responders arrived at the celebrity's home.

Following Perry's death, his "Friends" cast members issued a joint statement.

“We are all so utterly devastated by the loss of Matthew. We were more than just cast mates. We are a family. There is so much to say, but right now we’re going to take a moment to grieve and process this unfathomable loss,” said Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc, and David Schwimmer. “In time we will say more, as and when we are able. For now, our thoughts and our love are with Matty’s family, his friends, and everyone who loved him around the world.”

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