Israeli missiles have hit a site in Iran, according to confirmation from a U.S. official as first reported by ABC News. The official was unable to confirm whether the reports of additional Israeli strikes against military targets in Syria and Iraq were true. Iran has activated its air defenses over several cities, according to Iranian state media.

However, local sources report explosions in Iran’s city of Isfahan, the home of the Iranian regime’s nuclear and conventional-missile programs. Meanwhile, further explosions were reported near Baghdad, in an area used by Iran’s Islamic Revolutionary Guard Corps to meet with proxies in the region.

Israeli officials notified the Biden administration on Thursday that they planned to launch reprisal strikes against Iran within 24–48 hours, according to Bloomberg.

Dubai-based air carriers FlyDubai and Emirates were observed diverting around Isfahan, located in central Iran, in the early hours of Friday morning local time. Flights to Tehran, Shiraz, and Isfahan are suspended, per state media.

The reported strikes come hours after Iran’s foreign minister, Hossein Amir-Abdollahian, said in an exclusive interview with CNN that Iran’s response to military action from Israel would be “immediate and at a maximum level.”

Amir-Abdollahian remarks come after Iran’s Sunday attack when Iran launched approximately 300 missiles and drones at Israel in a blanketing effort to overwhelm Israeli missile defenses. Coalition forces, the U.S. foremost among these, shot down the overwhelming majority of the incoming munitions using a combination of ship- and aircraft-based weapons systems.

This is a developing story.