Iran launched a massive drone attack toward Israel Saturday night into Sunday morning local time, following through on its vow to retaliate against the Jewish state after several top Iranian commanders were killed in a suspected Israeli strike in Damascus earlier this month.

The Israeli military estimates that the attack involves over 100 drones, which won’t arrive in Israel for another few hours. Some reports indicate that the airborne operation will also include missiles. This would mark the first direct Iranian attack on Israeli soil.

On Friday, President Joe Biden said that Iran’s retaliatory attack against Israel was imminent and warned Tehran against carrying out the attack. “Don’t,” he said. U.S. officials believe the attack, once it hits Israel, will lead to a wider regional conflict that extends beyond Israel and Iranian proxies such as Hamas or Hezbollah.

Airspace in Israel, Iraq, and Jordan have been closed as the attack unfolds. U.S. and Israeli officials said they plan on intercepting the Iranian drones before they reach Israel, according to reports.

Following the onset of the hours-long operation, Iran’s supreme leader Ali Khameini vowed that Israel’s “malicious Zionist regime will be punished.”

“The malicious regime itself, which is all malice, evil and error, added another mistake to its own errors by launching an attack on the Iranian consulate in Syria,” the ayatollah said in a video posted to X. “The consulate and embassy offices in any country where they exist are regarded as the soil of the country to which the embassy belongs. Attacking our consulate is like attacking our soil.”

“The malicious regime has made a wrong move in this case. It should be punished and it will be punished,” he concluded.

Israeli foreign minister Israel Katz called for national unity in a social-media post amid the developing situation. “We all need to maintain our unity as a people and as a country in the face of the great challenges we face,” Katz wrote. “Only together will we win.”