The House passed a Republican-led resolution Tuesday to cancel the Environmental Protection Agency's heavy-duty vehicle emissions rule, setting up President Joe Biden's fourth veto.

The 221-203 vote on the measure, known as a Congressional Review Act resolution of disapproval, followed Senate passage of the resolution in April and stands in a line of similar measures advanced over the last few months that target the administration's environmental policies and regulations.

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Four Democrats supported the resolution and a single Republican opposed it.

Supporters of the resolution argued the final rule, which tightens the regulation of nitrogen oxides and particulate matter from heavy-duty vehicles, is too onerous and will drive up prices of trucks and the products they transport.

Rep. Bill Johnson (R-OH) said the regulations are impractical and unworkable.

"EPA's regulatory efforts are just the latest step by the Biden administration to electrify the transportation sector and burden American families in the process," Johnson said.

EPA finalized the rule in December and estimated it would reduce the risk of respiratory and other illnesses from vehicle emissions and result in between 860 and 2,900 fewer premature deaths in 2045.

The rule took effect in March but don't apply to new vehicles until model year 2027.

Democrats opposed the resolution, saying it would thwart progress at reducing pollution from the transportation sector.

"For some reason, anytime we have a success that is green, it just makes them see red," Rep. Lloyd Doggett (D-TX) said of Republicans. "Democrats are choosing to stand with families that are concerned about real health problems, like bronchitis, childhood asthma, and cardiovascular disease that is caused and accentuated by pollution."

Congress has approved multiple other CRA resolutions of disapproval, all of which have garnered some measure of bipartisan approval, including one to cancel the Biden administration's clean water rule. Biden vetoed the resolution in April.

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His other two vetoes involve resolutions to cancel the administration's moratorium on solar tariffs and its rule allowing retirement plan managers to weigh environmental and social issues when making investments, a reversal from the Trump administration.