The Israeli Air Force bombed Iran’s Isfahan nuclear site early Saturday for the second time since the start of the conflict, as Iran fired an overnight volley of five ballistic missiles at central Israel.

According to the military, some 50 IAF fighter jets were involved in overnight strikes, dropping 150 munitions on dozens of targets in Iran, including the Isfahan nuclear facility and four primed missile launchers.

The Israel Defense Forces said the strikes at the Isfahan nuclear site, which Israel had targeted on June 13, were intended to cause further damage to Iran’s nuclear program.

The strike on the first day of the conflict destroyed several critical sections, including uranium conversion infrastructure and labs, according to the IDF.

“Within the compound, a centrifuge production facility was also targeted, along with additional military targets of the Iranian regime in the Isfahan area,” the IDF said Saturday morning.

The military said it has caused “significant damage” to Iran’s centrifuge production capabilities, after also carrying out strikes on several such sites in Tehran earlier in the week.

Iran’s Fars news agency reported that there was no leakage of hazardous materials from the Isfahan site following the latest strikes.

Meanwhile, four primed ballistic missile launchers were “neutralized” in strikes before a salvo was launched at Israel, the military said.

Additional strikes overnight hit trucks used to launch drones at Israel, along with ballistic missile storage and launch infrastructure, and Iranian radars and air defense sites, the IDF added.

Overnight airstrikes in Iran also eliminated three top Islamic Revolutionary Guard Corps officers, including Saeed Izadi, head of the Palestinian Division in the IRGC Quds Force; Behnam Shahriyari, head of the Quds Force’s Unit 190; and Aminpour Joudaki, head of the IRGC Aerospace Force’s drone unit.

Meanwhile, Iran launched a barrage of five ballistic missiles at central Israel, triggering sirens in Tel Aviv and numerous surrounding towns at around 2:40 a.m.

The missiles were all intercepted by air defenses, according to military sources.

No impacts or injuries were reported, but interception fragments hit the roof of an apartment building in central Israel, sparking a fire. Firefighting teams headed to the scene and brought the blaze under control.

Additionally, the Israeli Air Force shot down several drones launched from Iran at Israel overnight and on Saturday morning, the military said. One drone crashed in an open area in the Golan Heights, causing no damage or injuries, according to the IDF.

Israel says its sweeping assault on Iran’s top military leaders, nuclear scientists, uranium enrichment sites and ballistic missile program is necessary to prevent the Islamic Republic from realizing its avowed plan to destroy the Jewish state.

Iran has launched over 470 ballistic missiles and around 1,000 drones at Israel since the IDF commenced operations against the Islamic Republic on June 13.

So far, Iran’s missile attacks have killed 24 people and wounded thousands in Israel, according to health officials and hospitals. Some of the missiles have hit apartment buildings, a university and a hospital, causing heavy damage.