Martin Clunes will be replaced by an Emmy-nominated US actor in a Fox remake of Doc Martin.

Clunes, who played the surgeon-turned-GP in 10 series of the hit ITV drama, has been ousted by Josh Charles.

Known for The Handmaid’s Tale, The Good Wife and Dead Poet’s Society, Charles will take on the lead in a new version of the set on the east coast of the USA.

The title will be changed to Best Medicine, with Charles portraying “a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child”.

“Unfortunately, Martin’s blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he’s all they’ve got,” the show’s publicity material reads.