Wall Street's main indexes fell at open on Tuesday as investors continued to grapple with the prospects of a prolonged restrictive monetary policy by the Federal Reserve and its subsequent impact on the economy.

The Dow Jones Industrial Average fell 144.20 points, or 0.42 percent, at the open to 33,862.68. The S&P 500 opened lower by 24.56 points, or 0.57 percent, at 4,312.88, while the Nasdaq Composite dropped 90.36 points, or 0.68 percent, to 13,180.96 at the opening bell.