Wall Street opened lower on Wednesday as investors awaited Federal Reserve Chair Jerome Powell’s speech for clues on the interest rate outlook.

The Dow Jones Industrial Average fell 45.36 points, or 0.13 percent, at the open to 33,881.38. The S&P 500 opened lower by 10.93 points, or 0.25 percent, at 4,367.48, while the Nasdaq Composite dropped 49.66 points, or 0.37 percent, to 13,506.02 at the opening bell.