This week we published one global cover, examining the growing push to enhance human capabilities, from brain-computer interfaces to life-extending drugs. We argued that the field should not be dismissed as the domain of cranks and quacks. Some methods show real promise, but separating science from snake oil will require rigorous trials and smarter regulation. Governments must rethink medical rules to encourage innovation while protecting against fraud. If real breakthroughs emerge, they could reshape society—and the world needs to be ready.