


Gene-editing drugs are moving from lab to clinic at lightning speed
The promising treatments still face technical and economic hurdles, though
One autumn day in 2020 Patrick Doherty was walking his dog up a steep mountain in County Donegal, Ireland, when he noticed he was, unusually for him, running out of breath. The eventual diagnosis was terrifying: amyloidosis, a rare genetic disease that caused a protein, amyloid, to build up in his organs and tissues. The prognosis was even worse: it would cause him years of pain until it finally killed him. In the face of such terrible fortune, though, Mr Doherty had a stroke of luck. He was able to join a trial of a new medical therapy and, with just a single injection, was apparently cured. Now, he continues to walk his dog up that steep mountain in County Donegal every week.

How America built an AI tool to predict Taliban attacks
“Raven Sentry” was a successful experiment in open-source intelligence

How Ukraine’s new tech foils Russian aerial attacks
It is pioneering acoustic detection, with surprising success

The deep sea is home to “dark oxygen”
Nodules on the seabed, rather than photosynthesis, are the source of the gas
Augmented reality offers a safer driving experience
Complete with holograms on the windscreen
Clues to a possible cure for AIDS
Doctors, scientists and activists meet to discuss how to pummel HIV
AI can predict tipping points before they happen
Potential applications span from economics to epidemiology