Toward the end of “A Real Pain,” a movie written and directed by Jesse Eisenberg coming to theaters on Nov. 1, two first cousins played by Eisenberg and Kieran Culkin approach the house in a Polish town where their recently deceased grandmother had lived before the Holocaust.

Eisenberg’s character, David, the more reserved of the pair, proposes the two leave stones on the doorstep, riffing on the Jewish tradition of placing stones on graves.

“She’s not buried here,” says Culkin’s cousin, Benji.

“Yeah, I know, but it’s the last place she was in Poland,” says David. “It’s the last place any of us were.”

The improvised remembrance, the interruption of self-awareness, the confused sense of duty — all are characteristic of how American descendants of the Holocaust’s victims two generations removed today commemorate an event that, nearly 80 years after it ended, can feel like something that still governs their lives, not to mention the lives of Jews and everyone else.

This cohort is known as the third generation of Holocaust survivors, and “A Real Pain” is representative of their output. Which is to say: It is often not about the Holocaust at all. The cousins go together on an organized tour of Holocaust sites and memorials in Poland, but much of it — excepting a visit to the Majdanek concentration camp — is lighthearted. David and Benji grieve mainly not for the Holocaust but for their grandmother, who survived it. They struggle with their own problems, including the dissipation of their relationship. They question why they are even there.