Though it was conceived in the Obama era, “The Handmaid’s Tale” arrived on Hulu in the early months of the first Trump presidency. Eight years later, it is concluding at the dawn of the second as an enduring, if initially accidental symbol of feminist resistance.

Like the 1985 Margaret Atwood novel it is based upon, “The Handmaid’s Tale” focuses on the violence inflicted on women in Gilead, a place plagued by low birthrates and environmental disasters that divides women, based on age and fertility, into Wives, Handmaids, Marthas, Aunts, Econowives and Unwomen.

From the beginning, the show has invited interpretation as a running commentary on real-world gender politics — female activists nationwide wore the Handmaid’s uniform of red cloaks and stark white bonnets in protests, and “The Handmaid’s Tale” made history as the first streaming series to win the Emmy for best drama, in 2017. And its dystopian conceit of a nation claiming complete control over women’s reproductive rights became only more ominous as more U.S. state legislatures passed abortion restrictions, culminating in the Supreme Court overturning Roe v. Wade in 2022.

“The Handmaid’s Tale” will end on May 27. (A spinoff series called “The Testaments” is currently in production.) The sixth and final season is focusing on the power of collective action, including unanticipated collaboration between the former enemies June Osborne (Elisabeth Moss) and Serena Joy (Yvonne Strahovski) in attempting to destroy Gilead and restore American democracy. (As a former Handmaid, June was routinely sexually assaulted by Serena’s husband, a high-ranking official.)

Multiple members of the creative team talked about “The Handmaid’s Tale” in recent video interviews, including Strahovski and Moss, who is also a producer and director on the series; Bruce Miller, the creator; Warren Littlefield, a producer; and Yahlin Chang and Eric Tuchman, the Season 6 showrunners (both were writers in earlier seasons).