Sean Combs, the embattled music mogul, has been indicted on three counts of sex trafficking, racketeering and transportation to engage in prostitution.

In the indictment, which was unsealed on Tuesday, prosecutors in the Southern District of New York accused Mr. Combs of running a “criminal enterprise” that for years threatened, abused and coerced women, and included accusations of forced labor, kidnapping, arson, bribery and obstruction of justice. To commit these acts, the prosecutors said, Mr. Combs relied on the help of the employees of his business.

Mr. Combs, 54, was expected to appear for an arraignment later on Tuesday at a federal courthouse in Manhattan.

“He’s going to plead not guilty, obviously,” Marc Agnifilo, one of Mr. Combs’s lawyers, said outside the courthouse on Tuesday morning. “He’s going to fight this with all of his energy and all of his might, and the full confidence of his lawyers. And I expect a long battle with a good result for Mr. Combs.”

The charges against Mr. Combs were revealed a day after he was arrested in a Manhattan hotel room, following a federal investigation that has been active since at least early this year. In March, federal agents raided his homes in Los Angeles and Miami Beach, Fla.

The arrest of Mr. Combs — a producer, record executive and performer who is also known as Diddy and Puff Daddy — makes him the highest-profile figure in the music world to face criminal charges for sexual misconduct since R. Kelly, the R&B singer who, after trials in New York and Chicago, was sentenced to more than 30 years in prison for child sex crimes, sex trafficking and racketeering.