Michael Urie is a compulsive performing chameleon.

Urie, known for his work on “Ugly Betty,” is portraying Sir Robin in the revival of Monty Python’s “Spamalot,” which opened on Nov. 16 at the St. James Theater. He described the show as “a high British comedy with classic musical theater, production numbers and fart jokes.”

Mr. Urie, 43, is also returning for season two of “Shrinking” on Apple TV+, and come January will shift stage roles when he takes a two-week leave of absence to perform in “Once Upon a Mattress” at Encores! opposite Sutton Foster. Then there is a play reading at the Roundabout Theater; a scripted podcast series; and postproduction work for the film “Goodrich” with Michael Keaton.

“The more I have going on, the better I am at each one,” Urie said. “I tend to say yes to everything.”

He moved to New York from Plano, Texas, when he was 19 to study at the Juilliard School and never left. In 2021, he and his partner of 15 years, Ryan Spahn, 43, a writer and actor, bought a one-bedroom apartment on the first floor of a prewar building on the Upper West Side.