The most powerful economic policymakers in the world will descend on Grand Teton National Park in Jackson, Wyo., next week for one of the most exclusive gatherings of the year.

The most hotly anticipated event at the conference, known informally as Jackson Hole, is a speech by Jerome H. Powell, the Federal Reserve chair. He will provide his economic outlook at the storied Jackson Lake Lodge on Friday morning at a time of immense uncertainty about the trajectory for inflation and the labor market and a drumbeat of calls from the White House to lower borrowing costs.

But first, lodge staff and conference organizers have had to deal with the bats.

A suspected colony of bats recently took up residence in a block of cabins on the property, which is run by the Grand Teton Lodge Company. The bats are thought to have snuck in through a small, roughly half-inch hole on the roof of one of the rooms and, through a connected attic space, accessed seven other cabins.

Seven of the eight bats were captured and screened for rabies, all of which tested negative. One was set free by a guest.

The bat scare is no small matter for the conference. The Federal Reserve Bank of Kansas City has held its invitation-only event at the lodge since 1982. It provides a forum for leading central bankers, current and former government officials and academics to debate the most salient topics of the day, from what constitutes a “neutral” level of interest rates that neither speeds up nor slows down demand to the seismic shifts taking root across the global economy.

The rustic lodge is the epicenter of the conference, where at any point over the three-day event policymakers can be found chatting about the latest bear or moose sightings in between discussions about the merits of a 2 percent inflation target.

Even the most high-profile of conference attendees are set to stay at the lodge for the get-together. So far, Christine Lagarde, the European Central Bank chief, is also confirmed to attend and speak.

But the bats arrived first.

The initial run-in with a guest staying in one of the cabins happened on June 2. After seven more encounters were reported by overnight visitors in that group of rooms, the lodge shuttered them. They remain closed for the remainder of the season even though the bats are no longer there.

The Wyoming Department of Health and the Centers for Disease Control and Prevention have reached out to hundreds of people from 38 states who stayed in the affected rooms from May 15 to July 27. There were over 200 reservations in total during that time, meaning over 400 to 500 people may have been impacted if some of those bookings were couples, said Emily Curren, a state public health veterinarian with the Wyoming Department of Health.

“There is no immediate threat to the public,” the National Park Service said in a statement on their website. Across the state, 259 bats have been tested by the University of Wyoming so far this year, and only two have tested positive for rabies.

Construction on the lodge, which was bankrolled by the financier and philanthropist John D. Rockefeller Jr., began around 1950 and was completed roughly five years later.

“We are proud to host the Symposium at a National Park site,” a spokesperson at the Kansas City Fed said in a statement. “We’ve been in close contact with the Lodge and are assured they are addressing this issue.”

Sarah Howe of the Grand Teton Lodge Company said the team had repaired any potential vulnerabilities, like torn screens or open crevices, across the property to ensure that everything was “buttoned up tight.” She also said that all rooms will now have information for guests laying out what to do if they come in contact with a bat or if there is one either in the room or in any of the indoor public spaces.

Ms. Howe said that when a bat is spotted, the lodge’s security team is immediately dispatched to catch the critter, after which it will be held for 24 hours while the staff waits to hear if there was any human contact with it. If it hasn’t come into contact with a guest and is acting normally, Ms. Howe said the bat will then be released. If there has been contact, the bat will be sent for testing. According to the C.D.C., a bat must be euthanized for testing to rule out rabies.

“We don’t want to expose anybody to anything that they don’t necessarily need to be exposed to,” Ms. Howe said.