Josh Radnor and Jordana Jacobs were married outdoors this month, amid a snowstorm, with their 164 snow-drenched guests shivering in the 20-degree evening air, as Dr. Jacobs read a 10-minute monologue about her beloved, and Mr. Radnor responded with a 10-minute soliloquy.

No strangers to extraordinary circumstances, the couple fell for each other while tripping on mushrooms.

It was February 2022, and Dr. Jacobs, a clinical psychologist, and Mr. Radnor, an actor and musician, were at a sound meditation retreat held in upstate New York, along with about 30 other people. There, they ingested a psychedelic mixture before lying on the floor at opposite sides of a large room. Masks covered their eyes as they listened to singing bowls and chimes.

That is when Mr. Radnor and Dr. Jacobs slid into the DMs of each other’s consciousness.

“That’s her,” Mr. Radnor, now 49, said a voice told him. “That’s your woman.”

Across the room and the psilocybin-infused metaverse, Dr. Jacobs, 36, was having a conversation with her heart.

“What do you have to tell me?” she asked it.

“You know that man over there across the room, Josh?” it replied. “You’re drawn to him.”