BALTIMORE — Giancarlo Stanton’s climb up the all-time home runs list has reached another milestone.

The Yankees slugger swatted his 450th career home run on Saturday night against the Orioles at Camden Yards, moving into sole possession of 41st on the all-time list.

Stanton moved past Vladimir Guerrero and Jeff Bagwell, who he had been tied with for the past week-plus, while recording his 21st home run of an injury-shortened season.

Up next on the all-time homers list is Carl Yastrzemski at 452.

The benchmark blast came in the first inning, a three-run shot against Orioles right-hander Tomoyuki Sugano to put the Yankees ahead 3-0.

Stanton missed the first two and a half months of this season with tennis elbow in both arms, but this is still the 14th time in his 16-year career that he has hit 20-plus home runs in a season.