Meg Ryan made a rare public appearance in New York City on Wednesday night, stepping out to support Michael J. Fox at a screening of his new documentary “STILL.”

The “Sleepless In Seattle,” star, 61, posed for photos with Fox, with many left enamored by the pair’s enduring friendship.

However, some social media pundits were distracted by the actress’s appearance, saying she was “unrecognizable” — and may have had some cosmetic tweaks.

“WTF has Meg Ryan done to her face?!” one baffled fan asked.

“Is that really Meg Ryan? If so that’s such a shame and incredibly sad,” another wrote, claiming the actress looked unrecognizable.

“Lay off the filler!!!” a third chimed in, that the beauty may have had some non-surgical work.

Meanwhile, several others claimed that the “When Harry Met Sally” star was starting to resemble Madonna, 64, who has also hit headlines for her age-defying visage.

“Her and Madonna obviously have the same plastic surgeon,” one declared.

“Meg Ryan and Madonna should team up for a horror flick,” another nasty Twitter troll stated.

Reclusive Ryan rarely makes public appearances. Wednesday’s outing was her first media event in more than six months.