Two men were killed and two others hurt in shootings across the Big Apple overnight, police said.

A man was fatally shot in the chest on 101st Avenue and 125th Street in Queens at around 4:20 a.m. Saturday, cops said.

The victim, 31, was later pronounced dead at Jamaica Medical Center, the NYPD said.

There are no arrests.

In the Bronx, a 24-year-old man was shot in the chest on Elder Avenue, near Boynton Avenue in Soundview at around 2:40 a.m. Saturday, cops said.

The victim was pronounced dead at Jacobi Hospital.

No arrests have been made.

Late Friday in the Bronx, two men, both 28, were shot on Pugsley Avenue, between Ellis Avenue and Gleason Avenue at around 10:50 p.m., police said.

One of the victims was shot in the chest and the other in the left leg, cops said.

Both men were being treated at Jacobi Hospital and are expected to survive, the NYPD said.

There are no arrests.

Cops are looking for two suspects who ran from the scene.