This autumn, the new restaurant openings nearly outnumber falling leaves.

The grim warnings of 2020 — dining-out was dead, life would forever be limited to takeout and delivery in foam containers — now seem foolish.

The incoming class has something for everyone. The biggest kitchen names are back — Vongerichten, Boulud, Carmellini, Samuelsson, Forgione, Bloomfield.

So are owners with grand-slam track records, including Simon Oren, John McDonald, and Simon Kim. Big debuts for sushi, mezze and wine sipping abound.

So get your calendar out and get ready to make some reservations.

Four Twenty Five (425 Park Ave., Jean-Georges.com, October) — the year’s most momentous restaurant opening by a mile — will bring together the great French chef Jean-George Vongerichten, a talented culinary director (Per Se veteran Jonathan Benno) and a Norman Foster-designed showplace at the new office tower 425 Park Avenue.

It aims to do for the Plaza District what Daniel Boulud’s Le Pavillon at One Vanderbilt did for the Grand Central area — bring an eating frenzy to its buttoned-down environs. French, American and Italian dishes with Asian flourishes are on the menu, which is heavy on vegetables. But, it’s neither vegetarian nor vegan as Daniel Humm, who originally was tapped for the tower, wanted.

The project will be closely watched not only by JGV’s loyal followers, but by New Yorkers who hope Midtown can get its mojo back.

It’ll be hard to miss.  A ground-floor cocktail lounge with a 45-foot-high ceiling and 80-seat mezzanine dining room with a vast open kitchen are already gleaming through the windows at the corner of Park Avenue and East 55th Street. 

JGV isn’t the only celebrated chef cooking up something exciting.

Daniel Boulud’s elegant Cafe Boulud (100 East 63rd St., CafeBoulud.com, November) —  a canteen to uptown glitterati, but welcoming to all is set to rise again in a new location.

The menu brings back the four original categories that set the place apart — La Tradition, La Saison, Le Potager and Le Voyage — and will be overseen by executive chef Romain Paumier, who’s the current executive sous chef at Restaurant Daniel and a veteran of the original.

French/Italian fare, such as lobster cannelloni au caviar is on the menu at Cafe Carmellini (250 Fifth Ave., CafeCarmellini.com), the latest from chef Andrew Carmelini (Locanda Verde, Lafayette).

April Bloomfield will open her first spot — a Brooklyn bistro called Sailor (228 Dekalb Ave., Sailor.nyc) —since the Spotted Pig shuttered in early 2020 in the wake of harassment allegations against owner Ken Friedman.

The city’s reigning noodle queen, Missy Robbins, is also expanding her empire with the recently opened Misipasta (46 Grand St., Brooklyn; MisiPasta.com) a casual market, cafe and aperitivo bar. Pick up some fresh fettuccine or malfadini to cook at home or grab a stool and a negroni.

Also making moves are Marc Forgione, who’s reopening Forgione (30 Hudson St.; MarcForgione.com; September) in the old Brushstoke space; Marcus Samuelsson, who has an unnamed project in the Perelman Performing Arts Center (251 Fulton St., PACYNYC.org, September); Jose Andres, whose Spanish/Japanese tasting menu spot, The Bazaar, just arrived at the Ritz Carlton NY Nomad (35 West 28th St., TheBazaaar.com); and the prolific Mexican-American chef Julian Medina, who will soon add Soledad (1825 Second Ave.;SoledadNYC.com) to his roster.

“It’s a tribute to my grandmother, but I am modernizing her recipes,” said Medina.

Drinks dominate at a number of debuts.

The always beloved Serafina is opening its first Serafina Restaurant and Wine Bar (110 University Place, SerafinaRestaurant.com, Septermber) where, in addition to pizza and pasta, there will be an extensive selection of wines, most of them Italian.

Renowned facial plastic surgeon Andrew Jacono and his fiction writer son AJ will premiere Bibliotheque (54 Mercer St., Bibliothequenyc.com, October) a Soho haunt where 10,000 books will share a space with 2,200 bottles of impressive wines —Chateau Petrus, anyone? — and original artwork by Henri Matisse, Damien Hirst and Roy Lichtenstein. 

Rockefeller Center continues to upgrade its offerings. The Tribeca cocktail lounge Smith and Mills will soon have a midtown location (30 Rockefeller Plaza; SmithandMills.com; October), featuring a raw bar and shared plates such as chilled crab with tomato dashi.

Across the East River, bar56 (53 Water St., Bklyn; Bar56Dumbo.com) has just opened in a landmark building beneath the Brooklyn Bridge, Creative cocktails, 56 wines by the glass, and dishes such as grilled lamb neck with spice yogurt are on the menu.

It will be easy to stick to a Mediterranean diet this fall.

Restaurateur Simon Oren and chef/partner Ari Bokozva, who have a hit in Dagon, will take another hefty swing with Acadia (101 West 57th St.; AcadiaNYC.com; October), a bi-level beauty with an open kitchen, a taboon oven and dishes such as rotisserie vegetables and foie gras skewers.

Bravo top chef finalist and former Kyma chef George Pagonis is opening his own place, Paros (211 West Broadway; September), with his brother Nicholas. Expect an extensive assortment of fish — including seafood imported from Greece.

A wide variety of Greek wines are the draw at Stafili Wine Cafe (222 W. Broadway, StafiliWineCafe.com), which just opened a second location in Lower Manhattan.

Meanwhile, in the Flatiron, upscale Turkish restaurant Nar (34 E. 20th St., NarRestaurant.nyc) just debuted, serving stylish interiors and dishes such as “Sultan’s Bliss’’ — smoked eggplant caviar and lamb shank

“Our food is more delicate and complex than most Turkish restaurants, and some of the recipes go as far back as Ottoman times’’ said partner Andy E. Arkun.

Expensive omakase spots have been the talk of the town in recent years, and the trend continues.

Keiji Nakazawa, one of the most legendary sushi chefs in the world, is coming to NYC with Sushi Sho (3 East 41 St. Sushi-Sho.com),

Also fighting for your hard-earned omakase dollars will be Bar Miller (620 East 6th St.; BarMiller.com; September.), an 8-seater from the team behind the East Village’s Mecca and Rosella; the kaiseke-inspired Tsubame (11 Park Pl.; no website, now open), where luxe ingredients like caviar and truffles swim with fish sourced from Japan; and Enso (117 Berry St., Brooklyn; October), where the 16 courses will come via chef Nick Wang, the man behind longtime Williamsburg favorites AKO and Amami.

Bangkok Supper Club (641 Hudson St., BangkokSupperClubNYC.com, September) The Fish Cheeks team says its latest endeavor is inspired by the Thai capital’s late night food scene.

Coqodaq (12 East 22nd St., Coqodaq.com, November) – Simon Kim follows up his hugely popular Korean steakhouse Cote with a Korean-fried chicken concept in a David Rockwell-designed space.

Delmonico’s (56 Beaver St., theoriginaldelmonicos.com, September) – The city’s oldest steakhouse is reopening its original FiDi location after a three-year closure.

John McDonald Unnamed project (201 Park Ave S.) The veteran restaurateur (Lure, Bowery Meat Company) will have a seafood restaurant in the W Hotel Union Square.

Naks (201 First Ave., September) The men behind the Indian hits Dhamaka and Masalawala & Sons will open their first Filipino restaurant.

Nōksu (49 West 32 Street, NYC, NoksuNYC.com, September) This 12-seat restaurant will serve a 15-course Korean tasting menu — down a staircase in the Herald Square subway station.