For only the 11th time in NCAA Tournament history — and for the third consecutive season — a No. 15 seed knocked off a No. 2.

New Jersey’s own Princeton University upended national powerhouse Arizona, busting brackets nationwide within six hours of the tournament’s opening tip.

Despite not leading until taking a one-point lead with 2:03 remaining, Princeton gradually overcame a 12-point deficit, escaping with a hard-fought 59-55 victory.

The Tigers ended the game on a 9-0 run in the final 4:28.

The win marks their first NCAA Tournament victory since 1998.

Princeton senior Tosan Evbuomwan led the way with 15 points, seven rebounds and four assists.

The Tigers will take on No. 7 Missouri — which defeated No. 10 Utah State, 76-65 — on Saturday in the round of 32.

It was second major upset of the day, after Furman handed Virginia its latest NCAA Tournament exit after JP Pegues made a 3-pointer with 2.4 seconds remaining for a 68-67 win.