Police fatally shot a knife-wielding man who charged at them after stabbing his wife at a family party packed with children in their Queens apartment, authorities and neighbors said.

The gathering on the second floor of a building on 62nd Street in Forest Hills turned tragic when a 46-year-old man knifed his partner at least twice in the stomach in front of other partygoers around 6:50 p.m., police and the neighbors said.

Police said there had been some sort of dispute, though it’s unclear over what.

Four cops, including a sergeant, were dispatched to the building and when they ascended the stairs, they ran into the suspect carrying a 12-inch knife in the second-floor hallway, Chief of Department Jeffrey Maddrey said at a Friday night press conference.

The cops ordered the man to “‘drop the knife’” but he refused and “charged” at them with the weapon, Maddrey said.

The sergeant then discharged his Taser while two officers fired their guns at least four times, striking the suspect.

Cops rendered aid until EMS showed up, Maddrey said.

Firefighters were seen performing CPR on the suspect, rushing him into a waiting ambulance.

The man, who neighbors said was from Uzbekistan, was taken to a nearby hospital, where he was pronounced dead.

His wife is being treated at a local hospital and is expected to survive.

The couple have children, and Maddrey confirmed several kids were present at Friday’s party.

Neighbors in the building on the tree-lined street said such violent crime is uncommon in the area.

“I’ve lived in this building for 10 years, nothing like this has ever happened,” said a man who lives on the same floor as the husband who knifed his wife.

The neighbor, who was at work when the incident took place, received a frantic call from his wife and rushed home.

When he arrived, he stumbled upon a grisly scene.

“There was blood in the staircase and in the hallway,” he said.

Additional reporting by Joe Marino and Larry Celona