An Uber driver was fighting for his life Tuesday after a passenger stabbed him during an attempted mugging on the FDR Drive in lower Manhattan, cops and police sources said.

The driver had a knife pulled on him as he was heading south on the parkway near the Manhattan Bridge at about 2:45 p.m., according to police and the sources.

The knife-wielding rider stabbed him — and then jumped out of the car and off the FDR to the roadway below in an attempt to escape, sources said.

The victim was taken to Bellevue Hospital, where he was in critical condition, cops said.

The passenger was taken to the same hospital and was in stable condition, according to police.