MINNEAPOLIS — The way their offense has been going lately, the Yankees can ill afford many mistake pitches or fielding miscues. 

They piled up a few too many on Tuesday night and it led to their first three-game losing streak of the season. 

The Yankees struck first, but it didn’t ultimately matter as their slipups proved too costly for their quiet offense to overcome in what turned into a 6-2 loss to the Twins at Target Field. 

With the win, the Twins (14-10) clinched their first season-series victory over the Yankees (13-11) since 2001.

Long tormented by the Yankees, the Twins have won four of the first six games between the teams this season ahead of the series finale Wednesday afternoon. 

The score Tuesday night was tied 2-2 heading into the sixth inning, when the Twins jumped on top for good against Nestor Cortes and Ron Marinaccio.

Jorge Polanco led off against Cortes with a deep fly ball to left-center field.

Left fielder Aaron Hicks made a long run to give himself a chance for a catch, but still couldn’t come up with it, just in front of the wall. 

Byron Buxton came up next and worked a full count before getting a 3-2 cutter over the plate and crushing it for a two-run home run.

That gave the Twins a 4-2 lead and knocked Cortes out of the game. 

Marinaccio entered from the bullpen and allowed an infield single around a pair of strikeouts.

But his first pitch to Trevor Larnach was a changeup that caught too much of the plate and was clobbered for another two-run homer to right-center field. 

The Yankees’ lineup, meanwhile, lacked that kind of thump against Twins right-hander Joe Ryan.

They scattered five hits (all singles) over the first two innings, but that led to just one run.

Ryan went on to mostly cruise across seven strong innings while striking out seven and walking none. 

Ryan, Jorge Lopez and Jhoan Duran retired 13 of the final 14 batters they faced to end the game. 

A night after Aaron Judge said the Yankees’ lineup had to be more aggressive early in games, he followed through and it paid off.

Bumped down a spot to hit third, Judge hit the first pitch he faced in the first inning for a single to left field. 

DJ LeMahieu came up next and, after Judge took second on a wild pitch, he smacked a single to the opposite field to give the Yankees a 1-0 lead. 

But Anthony Volpe’s third error in as many games opened the door for the Twins to take the lead in the third inning.

No. 9 hitter Michael A. Taylor led off with a ground ball to the left of second base.

Volpe reached down for it, but missed. 

Next up was Donovan Solano, who ripped a double to the left-field corner that scored Taylor from first to tie the score.

After Cortes struck out Carlos Correa, Jorge Polanco tagged him for another double to left field that put the Twins up 2-1. 

The Twins returned the favor, though, in the fifth inning. Hicks led off with a hard one-hopper that ate up Solano at first base.

Volpe followed with his third well-struck ball of the night, this one resulting in his second single of the game. 

One out later, Judge drilled a ground ball to third base that looked like an inning-ending double play.

But Solano failed to catch the throw at first, allowing Judge to reach safely and Hicks to come around to score to tie the score back up.