Warning: Photos of addictively smooth skin ahead.
Tired of paying for pricey in-office chemical peels? Me too. Though they’re unmatched for minimizing pores and fine lines and smoothening and brightening skin, the cost and time commitment are a bit much.
So it felt serendipitous when the editor-approved Noble Panacea Overnight Chronobiology Peel came my way. The celeb-approved skincare has graced the ageless faces of Salma Hayek and Jenna Lyons — plus supermodel Christy Turlington is such a fan, she’s even partnered with the brand.
Did my skin-goals celeb crushes know something that I didn’t?
The Overnight Chronobiology Peel is an at-home chemical peel created to work while you sleep, and each package includes eight treatments.
Made with Organic Super Molecular Vessels (OSMV), it’s designed to deliver active ingredients via tiny cells that are 10,000 times smaller than a skin cell. It also contains AHAs and BHA to target a plethora of skin woes, including fine lines, wrinkles, hyperpigmentation, acne scars, enlarged pores and uneven skin tone. (It’s meant to work with your sleep cycle, releasing soothing agents towards the end.)
The heavy-duty sustainable packaging opens to packets of a clear, unscented gel, packed with enough product to apply on your face, neck and décolleté.
The first time I slathered it on, I immediately felt a tingle — a must for me to feel like it’s working. You leave it on for five to ten minutes before applying your regular night cream, though I didn’t use it with retinol or other AHAs.
Over my 10 minutes of use, the sensation was there but not uncomfortable; it was on par with what I’ve experienced in a doctor’s office.
As I dozed off to bed, I noticed a glassy, taught look to my face. Hoping for the best, I said a little prayer, “Lord, make me glowy.”
While I was a bit concerned that I had tried it the night before an event — and didn’t want to wake up looking burned or flaky — thankfully that wasn’t an issue; the next morning, I awoke to slightly pink cheeks, and my pores seemed to have run away, as I couldn’t find them anywhere.
Eager for more benefits, I promptly contacted Noble Panacea to ask if I must wait a full week for the next application. The brand confirmed that if the first treatment doesn’t cause much sensitivity, two times per week is fine. I gleefully applied again after four days.
My skin began to acclimate, and it was a little less spicy the second time. I followed the same steps and awoke to glowy, soft and poreless skin — now, I’m hooked. Since I’m of the baby-oil-over-SPF generation, I have plenty of sun damage that I’m hoping to say goodbye to, thanks to this peel.
Also of note? For a “peel,” my skin doesn’t peel at all, which was unexpected — routine-wise, it’s more like using a mask.
While I’ve only applied it three times thus far, based on the results, I can’t wait to finish the treatment. According to the brand’s clinical trials, the results really start showing after four uses.
Noble Panacea was developed by a Nobel-prize-winning chemist, Sir Fraser Stoddart, with a science-based approach to skincare. Despite its lab origins, the line is made with non-irritating, planet- and human-friendly ingredients and is cruelty-free.
While I’ve tested my fair share of luxe skincare as a beauty editor, this overnight treatment has me waking up like I just got my favorite Hydrofacial: smooth, bright and soft, without any real irritation.
Though not inexpensive, it certainly saves me a bundle from seeing a facialist.
If you’re looking for a gentle yet effective anti-aging treatment that can be done from the comfort of your home, consider Noble Panacea’s The Exceptional Overnight Chronobiology Peel.
This article was written by Erica Radol, Page Six Commerce Reporter. From identifying the top anti-aging skincare secrets the stars trust to pinpointing the season’s next big fashion trends to finding a great deal on all of the above, Erica has a knack for reporting on – and even testing – Hollywood’s bestselling fashion and beauty products. Before joining Page Six in 2025, she wrote about entertainment, lifestyle and shopping trends for Us Weekly, The Daily Beast, Entertainment Tonight, Well+Good and Hearst.