A gunman on a Citi Bike shot a man in Harlem and another shooter wounded a woman on the Lower East Side as the weekend came to a bloody end in Manhattan, cops said. 

The first victim, a 37-year-old man, was blasted in the leg at West 144th Street and Adam Clayton Powell Jr. Boulevard around 6:50 p.m. Sunday, police said. 

Authorities say the man behind the trigger fled on a Citi Bike in an unknown direction, and had not been caught.

The victim was taken to Harlem Hospital and listed in stable condition, cops said.

Hours later, a 21-year-old woman took a bullet to the shoulder in front of a shelter at 78 Catherine Street in the Two Bridges section of the LES around 12:45 a.m. Monday, cops said. 

She was taken to Bellevue Hospital and also listed in stable condition, according to officials. 

Police did not immediately have any information on a suspect. 

The motives for both shootings are under investigation, and cops could not confirm whether either victim was an intended target.