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Jun 6, 2025  |  
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NextImg:Giants vs. Padres prediction: MLB Wednesday picks, player props, odds

The Giants and Padres are in the thick of the National League postseason race, but it isn’t because of their offenses. 

Both teams have struggled to score runs of late, and they will send a couple of arms that might be underestimated by oddsmakers to the mound on Wednesday night in San Francisco. 

In May, the Giants and Padres were both bottom-10 in baseball in wRC+ and home runs, defying their place in the standings. 

It hasn’t gotten much better during the early days of June. 

In the series opener on Monday night, the pair of teams went scoreless through nine innings before San Diego finally broke through in the 10th inning thanks to the ghost runner extra-innings rule, winning the contest 1-0. 

The Padres will give the ball to veteran right-hander Nick Pivetta, who is off to the best start of his career. 

In 11 starts, Pivetta has a Padres-best 2.74 ERA while striking out 10.25 batters per nine innings. 

He will counter Kyle Harrison, who recently re-joined the Giants’ starting rotation after an injury to Justin Verlander. 

San Francisco Giants starting pitcher Kyle Harrison throws during the second inning of a baseball game against the Washington Nationals, Saturday, May 24, 2025, in Washington.
Kyle Harrison throws during the second inning of the Giants’ 3-0 road loss to the Nationals on May 24, 2025. AP

Harrison has been excellent across two starts this season, striking out nine and giving up two runs over nine innings. 

These two bullpens rank top-five in the league in ERA as well, so even if the starters are knocked out early, it won’t be easy for either team to put runs on the board.

On paper, both teams should be hitting much better than they have for the last month-plus, but Wednesday night in one of the toughest pitcher-parks in baseball isn’t the time. 

The play: Giants-Padres under 7 (+100, BetMGM Sportsbook)

Dylan Svoboda is a versatile writer and analyst across many sports. He’s particularly knowledgeable about the big three — MLB, the NFL and the NBA.