The Giants could be on the verge of losing key components of both their front office and coaching staff.

Assistant general manager Brandon Brown was in Los Angeles on Wednesday for his second interview to be the Chargers general manager at the same time that offensive coordinator Mike Kafka was in Seattle for his second interview to be the Seahawks head coach, The Post confirmed.

The Chargers are looking to replace Tom Telesco, who was just hired to be the general manager of the rival Raiders and work with former Giants great Antonio Pierce as head coach.

At the same time they are interviewing GMs, the Chargers reportedly are negotiating with Jim Harbaugh to be their head coach.

Harbaugh and Brown have a personal relationship, sources say, though the root of that connection is unknown beyond interactions when Brown is scouting Harbaugh’s players at Michigan.

Brown was one of nine candidates in the Chargers’ first round of interviews.

If he is hired, the Giants will receive two compensatory third-round draft picks — one in 2024 and in 2025 — as part of the expanded Rooney Rule that rewards teams for developing minority leaders who are hired as general managers or head coaches.

Of course, Brown also would be privy to the Giants’ early thinking on all prospects at the top of the draft, including their preliminary plan at quarterback.

And the Chargers hold the No. 5 overall pick — one spot before the Giants are up.

Brown has been general manager Joe Schoen’s right-hand man on all roster decisions since he left the rival Eagles for a promotion just weeks after Schoen was hired in January 2022.

He had two interviews with the Panthers this month, but the team opted to stay in-house and promote Dan Morgan to general manager.

Kafka is one of five candidates so far called back for an in-person meeting by the Seahawks, according to Sports Illustrated.

Raiders defensive coordinator Patrick Graham — who previously held the position for the Giants — was up first, followed later in the week by two New Jersey natives, Cowboys defensive coordinator Dan Quinn and Rams defensive coordinator Raheem Morris, as well as Panthers defensive coordinator Ejiro Evero.

Quinn, a former Seahawks assistant and Falcons head coach, is thought to be the favorite.

If Kafka is hired, the Giants will need to replace all three of their coordinators, after Thomas McGaughey’s firing and Wink Martindale’s contentious exit.

Head coach Brian Daboll could call the plays next season whether Kafka returns or not.