ST. PETERSBURG, Fla. — There are games in which physical and mental mistakes are incidental and inconsequential.

Against a club that is off to a historic start, the Yankees did not have room for any kind of error.

Fundamental issues burned the Yankees in the 8-7, 10-inning loss to the Rays at Tropicana Field on Sunday, concluding a winnable series with a series defeat.

The most obvious gaffe arose in the sixth inning of a game that was tied.

Jimmy Cordero entered, walked Tampa Bay’s Jose Siri and advanced the runner to second on a wild pitch.

Siri would score on an error, but a mental one.

Siri took off for third base and got a big jump.

Cordero delivered to Yandy Diaz, who hit a tapper in between the mound and first base.

Cordero fielded it and did not check on Siri, who rounded third and kept coming home.

Cordero threw to first baseman DJ LeMahieu for the second out of the inning, but Siri scored all the way from second on a ball that traveled a couple feet.

“Got to be more aware in that situation,” manager Aaron Boone said of Cordero. “And a great break on the steal, in and of itself from second, so got to do a better job controlling their running game.”

Against the Rays, who became the seventh team since 1901 to win 19 of its first 22 home games, such mistakes — as well as a couple involving Gleyber Torres — aren’t optimal.

In the fifth inning, Torres was charged with an error that led to an unearned run.

With Diaz on first, Wander Franco hit a chopper over LeMahieu’s head, and Torres slid to stop it.

He got up and threw across the diamond to third baseman Oswaldo Cabrera, with Diaz trying to take the extra base.

The throw short-hopped Cabrera, who could not come up with the ball, enabling Diaz to get up and score.

A 6-1 Yankees lead became a 6-2 edge, and the Rays jumped ahead in the next inning against Gerrit Cole.

Perhaps Cole was tiring, and a bizarre play a few innings prior had led to his throwing a couple extra pitches.

In the second inning, with Harold Ramirez on first, Manuel Margot hit a high chopper to Torres, who charged the ball in front of the second-base bag.

He cleanly picked the ball but was then positioned too far in on the turf to step on the base or tag Ramirez.

Everyone was safe.

Though Cole escaped the jam by retiring Christian Bethancourt on three pitches, he had to record an extra out in the inning to do so.

“Certainly tough teams are going to capitalize on mistakes,” said Cole, who himself made too many. “In this situation, they did.”