Mayor Eric Adams announced the creation of a new government agency Tuesday to deal with the Big Apple’s $4.2 billion migrant crisis — and said he was in talks with other mayors across the US to take some migrants off his hands.

Adams said the Office of Asylum Seeker Operations would open a new, 24-7 processing center for arriving migrants and move those services out of the Port Authority Bus Terminal in Midtown Manhattan.

Adams said the new location would be “centralized” but didn’t say where or when it would open.

Workers will focus on helping adult migrants file the paperwork needed to get federal work permits, in addition to providing them and their families with “basic needs, like food and a safe place to sleep.”

“Our goal is to help them to become self-sufficient as soon as possible. That is the No. 1 goal,” he said during a news conference at City Hall.

Adams said that “no matter where I go, I’m hearing the same thing from the asylum seekers: ‘We don’t want to be a burden. We want to work. We want to be part of what this, all that we heard about being in this country.”

Hizzoner also said he was going to “move towards long-term housing and resettlement” of the city’s migrant population, which includes more than 30,900 living in 99 emergency shelters as of Sunday.

Adams said his plan included “resettlement to pre-vetted cities and municipalities that welcome asylum seekers.”

“There are many cities within the state and across the country that are saying they want to help. We want to create the pathway to do that,” he said.

But the mayor told pre-emptively told reporters not to ask for details, saying “I don’t need you running to the cities and stopping us from getting asylum seekers there.”

“We’ll tell you when they get there, you know, because I know you enjoy pitting cities against cities, so we’re not giving you that information,” he added.