Deion Sanders and Colorado’s hopes of an undefeated season have come to an end.

The No. 19 Buffaloes were blown out on the road by No. 10 Oregon, 42-6, on Saturday afternoon at Autzen Stadium.

Colorado dropped to 3-1, while Oregon is now 4-0.

The Ducks went up 35-0 at halftime and Colorado never recovered.

Colorado quarterback Shedeur Sanders was held in check, throwing for just 159 yards with one late touchdown in the fourth quarter.

Bo Nix for Oregon threw for three touchdowns and 276 yards.

The Buffaloes took 12 penalties for 105 yards.