Chris “Mad Dog” Russo will truly be unleashed this weekend when he plans to “bet the ranch” and “go crazy for the Buff” on Saturday afternoon.

The Mad Dog Sports Radio host laid out his Saturday plans as a guest on ESPN’s “First Take,” going all-in on the Colorado Buffaloes, who are 21-point underdogs on BetMGM as of Wednesday for their game against the Oregon Ducks.

“Here’s what I’m doing this weekend … I will get a run in, take the two dogs, Bo and Riley, for a walk. At about 12 o’clock, I’ll sit down, make an early cocktail. Cut a gummy in half,” Russo explained as co-guest Marc Spears looked on in hilarious shock.

“We got Florida State-Clemson, I like the Florida State quarterback, let’s do something there.”

But he truly has his eyes set on the Saturday afternoon game, starting with Deion Sanders’ Colorado Buffaloes opposite the Oregon Ducks at 3:30 p.m. ET. on ABC.

“At about 3:25, when I’m sauced, I’m not driving, in the house, 3:25. I’ll put the call into Fat Rob. 718-504 … ‘Rob ya know what, what the hell. I can’t root for Oregon. Alright, I’ll pretend on TV. Put 10 dimes on Colorado and Deion to win the game,'” Russo said while chuckling.

“So by 3:30 I’ll have [on] ABC … I will bet the ranch and I’ll go crazy for the Buff,” Russo said with a big grin on his face.

Russo isn’t the only one all in on Sanders’ Colorado Buffaloes, the team has garnered massive public betting appeal from bettors.

PointsBet’s lead trader, Kevin Lawler, told The Post that their “expectation is the line goes down a couple of points,” from the 21-point spread it currently is.

John Ewing reported that 73.5 percent of bets are on the Buffaloes to cover +21.5 on BetMGM, but 52 percent of the money is on Oregon, potentially showing sharp bettors are on Oregon.

For now, we won’t consider Russo one of those sharp bettors backing Colorado.