The woman who died suddenly while flying home to Indiana following a Dominican Republic vacation had suffered from a tragic medical condition, an autopsy revealed.

Stefanie Smith, 41, died from a carotid artery dissection in her neck on Feb. 28, a forensic pathologist told her family Wednesday, according to ABC News.

“It was truly a tragic medical event that happened,” Smith’s brother Chris Volz told the outlet.

The condition can compromise blood flow to the brain and lead to a stroke, the National Institute of Health said.

There was no foul play involved in the mysterious death of the seemingly healthy mother of two, which had baffled her family members and the public at large after making headlines earlier this month.

Smith had just enjoyed a five-night stay at the Iberostar Grand Bavaro in Punta Cana with her boyfriend and another couple.

She had gone jogging every morning of the trip and had sipped poolside mojitos and eaten a steak dinner the night before becoming fatally ill, her friend said.

Shortly after boarding her plane to the states, Smith began convulsing in her seat. The aircraft was diverted to Turks and Caicos, where she was pronounced dead at a hospital.

Her body was expected to be returned to the US next week, Volz told the network.

Smith left behind an 18-year-old son and a 16-year-old daughter.