Two people who were critically hurt in a Sunday afternoon blaze in Upper Manhattan have died from their injuries, as officials also confirmed that the fire was sparked by a lithium battery.

Two others injured in the 1 p.m. fire at 565 W. 190th Street in Fort George remain in “extremely critical” condition, FDNY Commissioner Laura Kavanagh said Tuesday.

Their names have not been released.

Kavanagh also confirmed earlier reports that a lithium battery sparked the fire — although not one on an e-bike as initially suspected.

“There was a bike that was pulled out and set in front of the building and initially — and incorrectly — people decided that bike was the case of the fire, which it was not,” the commissioner said.

“But once the marshals were able to get into the apartment they found a battery and that battery was the cause of the fire,” Kavanagh said.

She said there were “multiple lithium-ion batteries” in the fourth-floor apartment where the fire started.

So far this year, the batteries have sparked 76 fires in the five boroughs, injuring 60 people and killing seven people, topping the total for all of last year, Kavanagh said.

“It is quickly becoming one of the leading causes of fire deaths this year,” she said. “And we want to emphasize again: These fires are extremely dangerous. They create a large volume of fire very quickly and present significant threats to New Yorkers who try to get out of their homes and to our members as they respond to these calls.

“Please, please use these devices the way they’re supposed to be used.”

Kavanagh said the e-bikes should not be charged overnight or when residents are out, nor should they be stored near windows or exits. They should also have approved certification markings.

About 75 firefighters battled the Upper Manhattan and doused the flames after one hour, officials said.

The four people injured were taken to New York-Presbyterian Hospital.

In total, 45 people have been killed in fires in the Big Apple so far this year, Kavanagh said.