WASHINGTON — Senate Republicans plugged away overnight and into early Saturday morning to approve their multitrillion-dollar tax breaks and spending cuts framework, hurtling past Democratic opposition toward what President Donald Trump calls the “big, beautiful bill” that’s central to his agenda.

The vote, 51-48, fell along mostly party lines, but with sharp dissent from two prominent Republicans. It could not have come at a more difficult political moment, with the economy churning after Trump’s new tariffs sent stocks plummeting and experts warning of soaring costs for consumers and threats of a potential recession. Republican Sens. Susan Collins of Maine and Rand Paul of Kentucky both voted against the measure.