A company that bred beagles for medical research agreed Monday to pay a record $35 million as part of a criminal plea admitting it neglected thousands of dogs at its breeding facility in rural Virginia.

Prosecutors said the penalties amount to the largest ever levied in an animal-welfare case.

The plea deal also bars the company that operated the facility, Envigo RMS, as well as parent company Inotiv, from breeding or selling dogs in the future.