Bangladesh’s prime minister resigned and fled the country Monday, after weeks of protests against a quota system for government jobs descended into violence and grew into a broader challenge to her 15-year rule. Thousands of demonstrators stormed her official residence, a day after nearly 100 died in the unrest.

Prime Minister Sheikh Hasina’s departure threatens to create even more instability in the nation on India’s border already dealing with a series of crises, from high unemployment and corruption to climate change.