Donald Trump "completely obliterated" Iran's Fordow nuclear site using 12 massive 30,000-pound bunker buster bombs, US officials have confirmed.

The underground nuclear fuel enrichment facility was targeted by B-2 stealth bombers in what marks the first combat deployment of the GBU-57 Massive Ordnance Penetrator.

The precision-guided weapons, designed to penetrate deeply buried targets, can reach approximately 200 feet below the surface before detonating.

US military officials suggested that Fordow was "taken off the table" following the devastating strike, with Trump hailing the strikes as a "spectacular military success".

The strikes extended beyond Fordow, with two additional nuclear sites "wiped out" by 30 Tomahawk missiles launched from US submarines positioned 400 miles away.

Israeli Prime Minister Benjamin Netanyahu, who claimed Trump's decision "will change history", had specifically requested American assistance to destroy the heavily fortified Fordow facility.

B-2 stealth bombers, which were once described by military expert Kris Osborn as "nearly unstoppable", departed from Whiteman Air Force Base in Missouri on Saturday morning, flying non-stop for 37 hours with multiple mid-air refuelling operations.

The strategic bomber, produced by Northrop Grumman and valued at roughly $1billion per aircraft, has a range of about 7,000 miles without refuelling.

B-2 warplane dropping 'bunker buster' bombs

GBU-57 bombs, now known for its "bunker-busting" capabilities, can only be delivered by the B-2.

The weapon uses its weight and kinetic force to reach buried targets, with bombs capable of being dropped successively to drill deeper with each blast.

B-2 bombers, which can carry nuclear arms, has rarely been deployed in combat since first seeing action in Kosovo in 1999.

The aircraft most recently struck Yemen's Houthi rebels and their underground bunkers in October last year.

A picture of a B2 bomber in flight

Iran's missiles have caused damage in IsraelREUTERS

Following Trump's strikes, Iran vowed to retaliate against any US involvement in attacks on its territory.

Supreme Leader Ayatollah Ali Khamenei warned on Wednesday that American strikes would result in "irreparable damage" for the United States.

Iranian foreign ministry spokesman Esmail Baghaei declared that "any American intervention would be a recipe for an all-out war in the region".

Meanwhile, Iranian foreign minister Seyed Abbas Araghchi called the attacks "outrageous" and hinted at retaliation due to the "everlasting consequences" of America's strikes.

Fordow, Natanz, and Isfahan were all stuck in the strikesREUTERS

US presence in Middle East ahead of Donald Trump's verdict on an Iran attackGETTY

In a statement, Araghchi said: "The United States, a permanent member of the United Nations Security Council, has committed a grave violation of the UN Charter, international law and the NPT by attacking Iran's peaceful nuclear installations.

"The events this morning are outrageous and will have everlasting consequences. Each and every member of the UN must be alarmed over this extremely dangerous, lawless and criminal behavior.

"In accordance with the UN Charter and its provisions allowing a legitimate response in self-defense, Iran reserves all options to defend its sovereignty, interest, and people."

Trump has consistently maintained that he would not allow Iran to obtain nuclear weapons.

The Fordow facility's uranium enrichment plant is buried 80 to 90 metres beneath the surface - deeper than the Channel Tunnel connecting Britain and FranceREUTERS

Donald Trump in the Situation Room

Meanwhile, Trump issued a stark warning to Iran against retaliation, threatening even deadlier strikes if Tehran responds to the American assault.

"There will be either peace or there will be tragedy for Iran far greater than we have witnessed over the last eight days," he said.

Trump added: "Remember, there are many targets left. Tonight's was the most difficult of them all by far, and perhaps the most lethal.

"But if peace does not come quickly, we will go after those other targets with precision, speed and skill."