Donald Trump has demanded Iran's "unconditional surrender" as he teased US preparation for possible military action.

The US President also made bold claims that Iran's Supreme Leader Ayatollah Khamenei was an "east target" but would not be killed "at least for now".

Trump, who said America's patience with Tehran's regime was running out, has increased pressure on the Middle Eastern nation by assembling warships and fighter jets in the region.

He aligned the United States with Israel, boasting that “we” have “total control of the skies over Iran”.

Donald Trump teased the US's preparation for possible military action

US strikes on targets inside Iran, including nuclear facilities, were "on the table", according to Trump.

Trump said: "We know exactly where the so-called ‘Supreme Leader’ is hiding."

He added: "He is an easy target, but is safe there — We are not going to take him out (kill!), at least not for now. But we don’t want missiles shot at ­civilians or American soldiers. Our patience is wearing thin.”

It comes as the conflict enters its sixth day, with more strikes hitting Tehran in the early hours on Wednesday morning.

Missiles launched from Iran are intercepted as seen from the Israeli-occupied Golan Heights

The Israeli military reported that at least 60 of their air force jets were deployed overnight to target Iran's ballistic missile launchers in "an extensive wave of strikes in the heart of Iran."

An evacuation warning was issued by the Israeli military, warning citizens of Iran's capital near the city's international airport to escape to safety.

Iran retaliated by launching hypersonic missiles, which travel at more than five times the speed of sound, at Tel Aviv overnight, according to the Islamic Revolutionary Guard Corps.

Israel began strikes at the end of last week after fears the regime was close to producing a nuclear weapon.

Missiles launched from Iran are intercepted as seen from Tel Aviv

Tehran's last death toll update, published on Monday, had the death toll at 224; however, Human Rights Activists, based in Washington, claim the figure is at least 585.

On Monday, Trump left the G7 summit in Canada, telling reporters he was working on something "bigger than a ceasefire".