Matchday 32 could mark a historic moment for Napoli, who might be crowned champions of Italy for the first time since 1990.

This weekend is also featuring some head-to-head clashes that will play a key role in determining the fate of teams at both ends of the Serie A table.

Second-placed Lazio are visiting Inter Milan in a high-stakes fixture, as both clubs are deeply involved in the race for a top-four spot.

Maurizio Sarri’s side unexpectedly dropped points in the latest Serie A round and will look for redemption at Stadio San Siro. Captain Ciro Immobile, one of three strikers in the league history to have recorded at least 10 goals in seven consecutive Serie A seasons with the same club, might be back in the starting 11.

Inter Milan will try to capitalize on their formidable momentum following their successful run in domestic and international cups.

While Simone Inzaghi’s men have failed to be consistent in this Serie A campaign, they have been lethal in knockout competitions, clinching qualification to the UEFA Champions League semifinal and the Coppa Italia final.

Meanwhile, Roma are scheduled to host AC Milan on Saturday. The two sides are currently level on 56 points, and suffering a defeat might have serious consequences in their pursuit for a UEFA Champions League finish.

Argentine star Paulo Dybala will start on the bench after having picked up an injury in the final minutes of Roma’s away game at Atalanta, which was yet another unfortunate event in the Giallorossi’s injury-filled season.

“If needed, I will play on Saturday,” Roma head coach Jose Mourinho quipped in his post-match press conference.

AC Milan will travel to Rome to try ending their unsuccessful away streak this season, as they have won just three of the last 10 Serie A matches that weren’t played at San Siro.

Clinching a top-four position remains the main goal for the Serie A reigning champions, who have recently been able to build great excitement following the qualification to the UEFA Champions League semifinal, their first in 16 years.

At the bottom of the table, the game between Cremonese and Hellas Verona could be a watershed in the two teams’ fight for survival in Serie A.

While Cremonese have no option but to collect the three points to keep their hopes alive, Hellas Verona seek victory to climb out of the relegation zone. After struggling to generate positive momentum throughout the majority of this Serie A campaign, the Scaligeri have racked up seven points in the last three matches and are now one position away from safety.

Currently, Hellas Verona, Spezia, Lecce, Empoli and Salernitana are fighting to avoid the drop and are all standing within seven points, which makes the battle in the lower half of the table even more captivating.

Sampdoria and Cremonese respectively occupy the last and penultimate position. Unless they manage to turn the season around with a winning streak in the last seven Serie A rounds, they are bound to play Serie B soccer next year.

This could be the weekend that officially turns Napoli into the new Italian champions with six games to spare.

Luciano Spalletti’s men will clinch the league title in the event that they take care of business at home in the Campania derby against Salernitana and second-placed Lazio drop points to Inter Milan.

Winning the league represents a remarkable achievement for Napoli and the city as a whole, who have been waiting 33 years to put their hands on Italy’s much coveted Scudetto.

For the occasion, the league accepted the club’s request to push the game back from Saturday to Sunday: This way, Napoli will know the results of the Lazio game, and if things go according to plan, thousands of Partenopei fans are ready to unleash their joy in the vibrant Neapolitan streets.