Bob Barker, the host of the game show "The Price Is Right" and an animal-rights activist, died Saturday morning at his home of natural causes. He was 99.

“It is with profound sadness that we announce that the World’s Greatest MC who ever lived, Bob Barker has left us," Barker's publicist Roger Neal said in a statement.

Born on December 12, 1923, in Darrington, Washington, Barker worked part-time in radio while in college and was given his own radio show in 1950, The Bob Barker Show, which ran for six years. He began his game show career in 1956, hosting Truth or Consequences.

When his wife Dorothy Jo died at age 57 in 1981, Barker became an advocate for animal rights and animal rights activism. In 2007, he retired from hosting The Price Is Right after celebrating his 50-year career on television. In the years after his retirement, Barker continued to make occasional public appearances from 2009 to 2017.

Barker was a 19-time Daytime Emmy award-winner: 14 for Outstanding Game Show Host for “The Price Is Right” and four “Outstanding Game Show” awards as the show’s executive producer.

He subsequently hosted various game shows, and the Miss Universe and Miss USA pageants from 1967 to 1987, giving him the distinction of being the longest-serving host of those pageants. He began hosting The Price Is Right in 1972.

Barker was a winner of 19 Daytime Emmy Awards. Also received an Emmy Award for Lifetime Achievement in 1999 and was inducted into the Television Academy's Hall of Fame in 2004.