The South Dakota State Fire Marshal's Office is investigating a house explosion that killed two people.

The house near the town of Fort Pierre exploded around 10:20 a.m. Wednesday, KELO-TV reported. 

Names and ages of the victims have not been released. A man and two children also were hospitalized. Their conditions were not released.

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Stanley County Sheriff Brad Rathbun said neighbors in the rural area heard the blast and alerted authorities. The cause of the explosion is under investigation.