Joran van der Sloot left Peru on Thursday morning and is en route to the United States with agents from the Federal Bureau of Investigation.
Van der Sloot is the prime suspect in the May 2005 disappearance of Natalee Holloway in Aruba during a Mountain Brook High School, Alabama, senior trip.
The plane took off shortly before 8:00 a.m. from Jorge Chavez International Airport, according to van der Sloot's lawyer, Maximo Altez.
Altez has filed multiple appeals in attempts to stop the temporary extradition, but Peruvian courts didn't take action on them before his client's departure.
JORAN VAN DER SLOOT CASE: FBI PLANE LANDS IN PERU FOR TRANSFER OF PRIME NATALEE HOLLOWAY SUSPECT
Joran Van der Sloot (C) of the Netherlands is escorted by Peruvian police officers at the police headquarters in Lima June 5, 2010. Chile on Friday deported to Peru Van der Sloot who is wanted for the murder of 21-year-old Stephany Flores in Lima and has been linked to the 2005 disappearance of an American teenage girl in Aruba. (REUTERS/Pilar Olivares )
Joran Van der Sloot of the Netherlands (C) is transferred by the police to the Justice Palace to be held temporarily before being moved to a prison in Lima June 11, 2010. An official at the Peruvian national police's criminal investigations unit told Reuters on Tuesday that Van der Sloot admitted he killed 21-year-old Stephany Flores, whose body was found in a Lima hotel room last week. (REUTERS/Pilar Olivares)
In an earlier court filing, Altez says his client wasn't notified by Peruvian officials of the "temporary extradition" process that was ongoing against him, which Altez contends is a "serious constitutional violation."
Van der Sloot is expected to arrive in Birmingham, Alabama on Thursday afternoon.
The Dutch national was being held in a Peruvian prison for the murder of 21-year-old Stephany Flores in 2010. Van der Sloot was originally sentenced to 28 years in prison for the killing, but more time was added because of a drug smuggling scandal he was involved in while in jail.
Peruvian officials agreed in May to temporarily transfer the Dutch national to the United States in order to face federal charges.
JORAN VAN DER SLOOT WILL LIKELY BE TRANSFERRED TO US DESPITE LAST-MINUTE EFFORTS: INTERPOL OFFICIAL
Van der Sloot leaving Challapalca Prison. (APTN)
The body of Natalee Holloway hasn't been found. In January 2012, van der Sloot pleaded guilty to killing Flores. That same month, Natalee Holloway was legally declared dead.
Van der Sloot will now face charges of extortion and wire fraud in the United States after allegedly attempting to sell Beth Holloway, Natalee's mother, information regarding the location of her daughter's body.
Federal prosecutors say van der Sloot asked for $250,000 — $25,000 upfront for the information and the rest to be paid out when the body of Natalee Holloway was positively identified.
Natalee Holloway was last seen alive in Aruba while on a Mountain Brook high school senior trip. (Federal Bureau of Investigation)
However, van der Sloot lied to Beth Holloway's lawyer, John Q. Kelly, about where her daughter's remains were located, according to American prosecutors.
In an earlier statement provided to Fox News Digital when the Peruvian court announced the transfer of van der Sloot, Beth Holloway, Natalee's mother, said this gives a chance for justice to finally be served.
Beth Holloway, mother of Natalee Holloway, speaks during the opening of the Natalee Holloway Resource Center (NHRC) at the National Museum of Crime & Punishment in Washington, June 8, 2010. Natalee, 18, of Mountain Brook, Alabama, vanished while on a high school graduation trip to Dutch-owned Aruba, an island in the Caribbean in 2005. She never showed up for a flight home and her disappearance made international headlines. (AP Photo/Pablo Martinez Monsivais)
"I was blessed to have had Natalee in my life for 18 years, and as of this month, I have been without her for exactly 18 years. She would be 36 years old now," Beth Holloway said. "It has been a very long and painful journey, but the persistence of many is going to pay off. Together, we are finally getting justice for Natalee."