Both of the deceased were bicyclists.
"We are sad to update that this is a fatal crash with two confirmed deceased cyclists. One adult female and one adult male. This crash involved a single vehicle (pick-up truck). The adult male driver remained on scene," police said.
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Goodyear police said the driver of the pickup truck involved in the crash, who was not identified, remained at the scene. (Goodyear Police Department/Facebook)
Eleven others were taken to area hospitals with "various" injuries, police said.
Cotton Lane was subsequently closed in both directions "from the circle at Estrella Parkway to MC85" for several hours, police said.
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They are continuing to investigate the cause of the crash.
Goodyear police spokesperson Lisa Berry said the driver of the pickup truck, who was not identified, remained at the scene. It is not immediately clear if the driver was arrested.
Police have not released further information about what caused the crash. It is not known if the driver was impaired or speeding.
Goodyear Police investigating a serious injury crash on Eastbound McDowell. This photo is unrelated to the contents of this report. (Goodyear Police Department )
A short time later, another crash was reported in the Goodyear area, involving at least four vehicles.
Three victims, including an elderly man, a pregnant woman, and a 7-year-old girl were transported to the hospital, AZFamily reported.
The Associated Press contributed to this report.