Former President Donald Trump and Vice President Kamala Harris will debate on Tuesday in what is likely to be the most significant single event in their battle for the White House.

With polls showing a tight race, the stakes are sky high because the first debate between candidates typically draws a huge audience and has the rare potential to shift opinions of millions of voters all at once.

This presidential debate is crucial for another reason: Harris and Trump have never met or interacted with one another. Americans will get to judge for themselves how they match up and which one they want to lead the country for the next four years.

The debate airs on ABC at 9 p.m. EST/6 p.m. PST. It will run for 90 minutes and be moderated by John Muir and Linsey Davis.

This is the only confirmed matchup that the candidates have agreed to after several weeks of uncertainty and wrangling. Trump had originally said he would skip the debate but later said he would do it. Since then, there have been arguments over its terms, including whether to mute their microphones.

Watch live as the debate gets underway:

New York Daily News’ Dave Goldiner and Bay Area News Groups’ Gieson Cacho contributed to this report.