The Celtics were missing two-fifths of their starting lineup Friday as they looked to snap their first losing streak of the season.

Boston ruled out guard Jrue Holiday (right shoulder impingement) and center Kristaps Porzingis for its matchup with the Indiana Pacers at TD Garden. Both players initially were listed as questionable.

It was the second consecutive DNP and fifth of the season for Holiday. It’s unclear whether his shoulder issue has contributed to his dip in 3-point shooting percentage, which is down more than 10 points from last season (42.9% to 32.6%).

Porzingis suffered his injury during the Celtics’ Christmas Day loss to the Philadelphia 76ers. He tweaked his ankle early in the game, played 13 minutes in the first half and did not emerge from the locker room after halftime.

It was the third injury the 7-foot-2 big man sustained since returning from offseason leg surgery on Nov. 25. The first two (an ankle tweak and a heel bruise) proved minor and did not cause him to miss time. The severity of his latest ailment was unclear as of Friday evening.

Head coach Joe Mazzulla did not provide an update on either player during his pregame news conference.

The 2024-25 Celtics have yet to play a full game with all eight of their core rotation players (Jayson Tatum, Jaylen Brown, Derrick White, Holiday, Porzingis, Al Horford, Payton Pritchard and Sam Hauser) available. That group has missed a combined 48 games this season.

Boston entered Friday with a 3-4 record over its last seven contests.