Rose Byrne and Seth Rogen reteam with “Platonic,” a new AppleTV+ comedy series launching Wednesday.

They first worked on “Neighbors,” the 2014 campus comedy about rowdy frat boys, and then its 2-year-later sequel.  “Platonic,” which revolves around whether guys can really be “just friends” with women, is co-created and directed by their “Neighbors” helmer Nick Stoller.

“I didn’t want to do the show if we didn’t have Seth,” Byrne, 43, said in a Zoom interview with Rogen.  “Having worked together for the ‘Neighbors’ movies I knew we would be having fun and enjoying each other. Just a nice dynamic onscreen.

“A show like this lives — and dies! — on the chemistry of the friendship. It really does. We went in knowing we had that. Since we aren’t a married couple, this was different but really exciting and made me want to do the show.”

“Part of the appeal,” Rogen,  41, said, “was bringing this theatrical style, R-rated adult comedy to a half-hour serialized television show.

“It felt very original in a lot of ways. But also allowed us to do stuff that we thought we were good at.”

As to the show’s Big Question, can people be platonic friends without getting mates or significant others jealous?

“It should,” Rogen answered.  “I do fundamentally think that men and women can be platonic friends with one another. People project a lot onto relationships and jealousy can come out if you’re insecure. I personally believe that you can have platonic relationships. I have many of them and so the proof is in the pudding.”

“I did have a deep, dear friend who’s a guy,” Byrne recalled. “We were roommates. But nobody could believe that we weren’t together — which is one of the reasons I found this quite relatable, the story and an examination of that.

“Because in the end, it’s really what everybody else is asking you rather than what you say.”