The Red Sox lost a pair of pitching prospects in the Major League portion of the Rule 5 Draft on Wednesday, with left-hander Shane Drohan selected No. 4 overall by the Chicago White Sox and right-hander Ryan Fernandez going No. 6 to the St. Louis Cardinals.

Drohan, 24, was Boston’s No. 19 overall prospect according to MLB Pipeline. The left-hander got off to a fantastic start this past season in Double-A but struggled badly following his promotion to Triple-A. The Red Sox subsequently left him unprotected in the Rule 5 Draft and it was widely expected he might be taken by another team.

Fernandez, 25, is another arm believed to be a candidate for Rule 5 selection. The hard throwing reliever boasts great stuff, including a fastball touching 99 mph, and he projects as someone who could realistically stick in a big league bullpen.

By rule, players selected in the MLB phase of the Rule 5 Draft must stay on their new team’s active big league roster for the full season. If they don’t, they must be offered back to their former team.

The Red Sox did not make any selections in the MLB phase of the Rule 5 Draft, but they did make one in the Minor League portion, selecting catcher Mickey Gasper from the New York Yankees’ Double-A roster.

Boston lost seven additional prospects in the MiLB phase, the most notable being Worcester Red Sox infielder Ryan Fitzgerald, who has drawn renown among certain segments of the fanbase for his annual spring training heroics and his energetic style of play in Worcester. He was selected with the first pick of the third round by the Kansas City Royals.

The other prospects selected from Boston’s minor league system included RHP Jose Ramirez (Low-A, Chicago White Sox), INF Johnfrank Salazar (Low-A, St. Louis Cardinals), OF Alexis Hernandez (Low-A, Toronto Blue Jays), RHP Railin Perez (Low-A, Houston Astros), RHP Ryan Miller (Double-A, Los Angeles Angels) and RHP Brock Bell (High-A, Cincinnati Reds).