Patriots offensive coordinator Bill O’Brien offered a glimpse into this weekend’s matchup with the Chiefs during a Tuesday video conference with reporters.

O’Brien noted Kansas City, which ranks third in the points allowed at 17.5 per game, uses several different personnel groupings and schemes under defensive coordinator Steve Spagnuolo. The Chiefs also blitz at the sixth-highest rate in the league, which is given the Patriots rank in the bottom 10 against the blitz in most categories.

Said O’Brien: “They’re smart, they do a lot of different things and they present a lot of challenges. So we have to have a really good week of practice.”

Patriots wide receivers coach Troy Brown added: “They pose a lot of different threats defensively, especially up front. In the secondary, they all do a really good job of playing their roles and doing their jobs, so we have our work cut out for us, as far as the receivers getting open against these guys. Their tough matchup guys, and they play physical in the secondary, so we’ve gotta come out and play well.”

On Tuesday, Pats linebackers coach Jerod Mayo reiterated his desire to be a head coach one day and said it would be “great” to remain in New England, but kept the door open to taking a head job elsewhere. … Ex-Patriots tight end Rob Gronkowski and wide receiver Julian Edelman took shots at the Colts during an appearance on Edelman’s “Games with Names podcast when they reflected on past matchups with Indianapolis. Said Gronkowski: “I absolutely hate the Colts, bro. They always needed some B.S. answer on why they kept losing to us every single year.” … The Patriots opened as 9.5-point underdogs against Kansas City, the largest spread they’ve faced at home since Week 3 of the 2001 season, Tom Brady’s first NFL start.